Semaglutide Raw Powder

For obese patients, Semaglutide treatment resulted in an average weight loss of 17% -18% within 68 weeks. In addition, Semaglutide is also approved by FDA for obese adults with a BMI ≥ 30 kg/m2 or for overweight adults with at least one weight related disease (such as hypertension, type 2 diabetes or dyslipidemia) (BMI ≥ 27 kg/m2).

Q1：What is the raw material for semaglutide?

A2：The raw material for semaglutide is a synthetic peptide made through solid-phase peptide synthesis (SPPS). This process uses a sequence of amino acids that mimic the natural GLP-1 (glucagon-like peptide-1) hormone.

1.Amino Acids (Peptide Backbone):

• Semaglutide consists of 31 amino acids arranged in a specific sequence to activate the GLP-1 receptor.

2.Fatty Acid Chain (Lysine Modification):

• A C18 fatty acid chain is attached to the peptide to prolong its half-life, allowing for once-weekly dosing by slowing degradation and enhancing albumin binding.

3.Excipients (for Formulation):

• These include saline, stabilizers, and solvents to prepare the final injectable solution.

1.Peptide Synthesis:

Each amino acid is sequentially linked to build the full peptide chain.

2.Purification:

The raw peptide undergoes chromatography to ensure purity.

3.Modification (Fatty Acid Addition):

The lysine residue is acylated with the C18 fatty acid.

4.Formulation:

The purified semaglutide peptide is combined with stabilizers for pen injector preparation.

Q2：How to mix semaglutide powder with water?

A2：Mixing semaglutide powder with water (reconstitution) should be done carefully to ensure proper dosing and effectiveness. Here's a general guide, but always follow the instructions from your provider or pharmacist.

• Semaglutide powder (vial)


• Bacteriostatic water (or sterile water for injection)


• Syringe (1-3 ml)


• Alcohol wipes


• Mixing needle (18-21 gauge)

1. Sanitize

• Wipe the top of the semaglutide vial and bacteriostatic water vial with alcohol.

1. Draw Water

• Use the syringe to draw the recommended amount of bacteriostatic water (typically 1-2 ml, depending on the concentration desired).

1. Inject Water into Semaglutide Vial

• Slowly inject the bacteriostatic water into the semaglutide vial, aiming for the side of the vial (not directly onto the powder) to avoid foaming.

1. Dissolve the Powder

• Gently swirl (don't shake) the vial until the powder fully dissolves. This may take a few minutes. Avoid creating bubbles.

1. Inspect the Solution

• Ensure the solution is clear and free of particles. If cloudy or not fully dissolved, swirl again or consult your provider.

• Store the reconstituted solution in the refrigerator (typically between 2°C-8°C / 36°F-46°F).


• Use within 28 days unless otherwise instructed.


• Draw your dose from the vial for weekly injections.

• Concentration: Know the final concentration (e.g., 1 mg/ml) to calculate your dose accurately.


• Sterility: Always use bacteriostatic water to prevent contamination.


• Accuracy: Small miscalculations can lead to dosing errors.